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CANCER

PERK links the clock and protein stress in cancer

The unfolded protein response (UPR) regulates cell metabolism and survival in response to stress, yet how the UPR is connected to other signalling pathways is poorly understood. PERK is now shown to regulate Bmal1 and Clock proteins to promote cancer cell survival, revealing a link between growth regulation and circadian rhythms.

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Fig. 1: Engagement of the UPR shifts the timing of circadian rhythms.
Fig. 2

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Correspondence to Chris Bakal.

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Sanchez-Alvarez, M., Bakal, C. PERK links the clock and protein stress in cancer. Nat Cell Biol 20, 4–5 (2018). https://doi.org/10.1038/s41556-017-0019-6

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