We have developed a versatile approach for promoting the penetration of commensal bacteria into the intestinal mucosa, by coating the bacterial surface with poly(ethylene glycol) (PEG). PEGylation-enabled penetration facilitated the preferential localization of bacteria at the mucus layer of the intestinal mucosal barrier, thereby reinforcing this barrier.
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References
Turner, J. R. Intestinal mucosal barrier function in health and disease. Nat. Rev. Immunol. 9, 799–809 (2009). A review article that presents the fundamental role of the intestinal mucosal barrier in host health.
Cai, R. et al. Interactions of commensal and pathogenic microorganisms with the mucus layer in the colon. Gut Microbes 11, 680–690 (2020). A review article that presents the interactions between the microbiota and the intestinal mucus layer.
Huckaby, J. T. & Lai, S. K. PEGylation for enhancing nanoparticle diffusion in mucus. Adv. Drug Deliv. Rev. 124, 125–139 (2018). A review article that presents an overview of PEG-based mucus-penetrating nanoparticles for oral drug delivery.
Lin, S. et al. Surface-modified bacteria: synthesis, functionalization and biomedical applications. Chem. Soc. Rev. 52, 6617–6643 (2023). A review article that presents the synthesis, functionalization and biomedical applications of surface-modified bacteria.
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This is a summary of: Chen, Y. et al. Reinforcement of the intestinal mucosal barrier via mucus-penetrating PEGylated bacteria. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-024-01224-4 (2024).
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PEGylated bacteria penetrate mucus and strengthen the gut mucosal barrier. Nat. Biomed. Eng 8, 804–805 (2024). https://doi.org/10.1038/s41551-024-01231-5
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DOI: https://doi.org/10.1038/s41551-024-01231-5
