Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cancer immunotherapy

Polypeptide agonists of innate immune sensors

The physicochemical properties of cationic helical polypeptides can be optimized to induce endoplasmic reticulum stress in antigen-presenting cells so as to elicit antitumour innate immune responses.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: The degree of helicity and serum stability of a polypeptide agonist affects its antitumour activity.

References

  1. Irvine, D. et al. Nat. Rev. Immunol. 20, 321–334 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Harrington, K. J. et al. Ann. Oncol. 29, viii712 (2018).

    Article  Google Scholar 

  3. Meric-Bernstam, F. et al. Clin. Cancer Res. 29, 110–121 (2023).

    Article  CAS  PubMed  Google Scholar 

  4. Patel, S. A. et al. Immunity 48, 417–433 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Lee, D. Y. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-024-01194-7 (2024).

    Article  PubMed  Google Scholar 

  6. Ramanjulu, J. M. et al. Nature 564, 439–443 (2018).

    Article  CAS  PubMed  Google Scholar 

  7. Chin, E. N. et al. Science 369, 993–999 (2020).

    Article  CAS  PubMed  Google Scholar 

  8. Pan, B.-S. et al. Science 369, aba6098 (2020).

    Article  Google Scholar 

  9. Dane, E. et al. Nat. Mater. 21, 710–720 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Dosta, P. et al. Nat. Nanotechnol. 18, 1351–1363 (2023).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Natalie Artzi.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Dion, M.Z., Artzi, N. Polypeptide agonists of innate immune sensors. Nat. Biomed. Eng 8, 495–496 (2024). https://doi.org/10.1038/s41551-024-01212-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41551-024-01212-8

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer