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Anchoring immunosuppression to inflamed tissue

Fusing the anti-inflammatory enzyme indoleamine 2,3-dioxygenase to the tissue-anchoring protein galectin-3 ameliorates inflammation at the injection site while avoiding systemic immune suppression, as shown in multiple rodent models of inflammation.

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Fig. 1: Effects of the IDO–Gal3 fusion protein in rodent models of inflammation.


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Correspondence to Gabriel A. Rabinovich.

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Mariño, K.V., Blidner, A.G. & Rabinovich, G.A. Anchoring immunosuppression to inflamed tissue. Nat. Biomed. Eng 7, 1060–1062 (2023).

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