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A hydrogel-entrapped live virus immunization

Confining the Zika virus within a self-adjuvanting hydrogel that forms a subcutaneous inflammatory niche stimulates strong immune responses in mice without inducing infection.

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Fig. 1: An entrapped live Zika virus as a vaccine.


  1. Baud, D., Gubler, D. J., Schaub, B., Lanteri, M. C. & Musso, D. Lancet 390, 2099–2109 (2017).

    Article  PubMed  Google Scholar 

  2. Pierson, T. C. & Diamond, M. S. Nature 560, 573–581 (2018).

    Article  CAS  PubMed  Google Scholar 

  3. Zhou, K. et al. Vaccines 9, 1004 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Bettini, E. & Locci, M. Vaccines 9, 147 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Uddin, M. N. & Roni, M. A. Vaccines 9, 1033 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Thompson, M. R., Kaminski, J. J., Kurt-Jones, E. A. & Fitzgerald, K. A. Viruses 3, 920–940 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Hao, H. et al. Nat. Biomed. Eng. (2023).

  8. Wieckiewicz, M., Boening, K. W., Grychowska, N. & Paradowska-Stolarz, A. Mini Rev. Med. Chem. 17, 401–409 (2017).

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Michael J. Mitchell.

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Gong, N., Hamilton, A.G. & Mitchell, M.J. A hydrogel-entrapped live virus immunization. Nat. Biomed. Eng 7, 849–850 (2023).

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