We developed an at-home microsampling approach that measures thousands of metabolites, lipids and proteins in small volumes of blood. Dense multi-omic sampling generates a ‘molecular movie’ that integrates with data from wearables to reveal new insights into the dynamics of human physiology.
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Chen, R. et al. Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell 148, 1293–1307 (2012). First demonstration of integrated personal omics profiling to characterize and prevent health issues.
Li, X. et al. Digital health: tracking physiomes and activity using wearable biosensors reveals useful health-related information. PLoS Biol. 15, e2001402 (2017). Early examples of using wearables data to detect health events and individual phenotypes.
Schüssler-Fiorenza Rose, S. M. et al. A longitudinal big data approach for precision health. Nat. Med. 25, 792–804 (2019). Presents an analysis of deep omics profiling of more than 100 individuals, revealing many clinical insights.
Dunn, J. et al. Wearable sensors enable personalized predictions of clinical laboratory measurements. Nat. Med. 27, 1105–1112 (2021). Study showing that wearable data can predict the level of clinical analytes.
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This is a summary of: Shen, X. et al. Multi-omics microsampling for the profiling of lifestyle-associated changes in health. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-022-00999-8 (2023).
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Dynamic monitoring of thousands of biochemical analytes using microsampling. Nat. Biomed. Eng (2023). https://doi.org/10.1038/s41551-023-01005-5