In this study, spherical nucleic acids (SNAs) were designed using defined placements of two classes of antigen that each activate different types of T cell. Use of SNA modularity illustrated the role of antigen placement within a vaccine architecture on subsequent processing and immune responses. The study defines design rules for multi-antigen vaccines.
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This is a summary of: Teplensky, M. H. et al. Multi-antigen spherical nucleic acid cancer vaccines. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-022-01000-2 (2023).
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Rational vaccinology maximizes the efficacy of multi-antigen vaccines. Nat. Biomed. Eng 7, 851–852 (2023). https://doi.org/10.1038/s41551-023-01002-8