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A biomaterial infused into the bloodstream repairs inflamed tissue

An extracellular matrix biomaterial delivered into the bloodstream selectively binds to blood vessels in inflamed tissues, such as those caused by myocardial infarction and traumatic brain injury. The biomaterial dampened the inflammatory response and promoted tissue repair and regeneration when tested in rat and pig models of myocardial infarction.

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Fig. 1: iECM targets leaky vasculature in inflamed tissue.


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This is a summary of: Spang, M. T. et al. Intravascularly infused extracellular matrix as a biomaterial for targeting and treating inflamed tissues. Nat. Biomed. Eng. (2022).

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A biomaterial infused into the bloodstream repairs inflamed tissue. Nat. Biomed. Eng 7, 92–93 (2023).

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