An extracellular matrix biomaterial delivered into the bloodstream selectively binds to blood vessels in inflamed tissues, such as those caused by myocardial infarction and traumatic brain injury. The biomaterial dampened the inflammatory response and promoted tissue repair and regeneration when tested in rat and pig models of myocardial infarction.
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References
Christman, K. L. Biomaterials for tissue repair. Science 363, 340–341 (2019). A perspective that discusses the use of acellular biomaterials for tissue repair and regeneration.
Serpooshan, V. & Wu, S. M. (eds) in Cardiovascular Regenerative Medicine: Tissue Engineering and Clinical Applications Ch. 10 (Springer, 2019). A book chapter that presents various injectable biomaterials for treating MI.
Singelyn, J. M. et al. Catheter-deliverable hydrogel derived from decellularized ventricular extracellular matrix increases endogenous cardiomyocytes and preserves cardiac function post-myocardial infarction. J. Am. Coll. Cardiol. 59, 751–763 (2012). An initial study showing the efficacy of an ECM hydrogel in a rat MI model.
Seif-Naraghi, S. B. et al. Safety and efficacy of an injectable extracellular matrix hydrogel for treating myocardial infarction. Sci. Transl Med. 5, 173ra25 (2013). A study showing the efficacy of an ECM hydrogel in a porcine MI model.
Traverse, J. H. et al. First-in-man study of a cardiac extracellular matrix hydrogel in early and late myocardial infarction patients. JACC Basic Transl Sci. 4, 659–669 (2019). The first study testing an ECM hydrogel in patients.
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This is a summary of: Spang, M. T. et al. Intravascularly infused extracellular matrix as a biomaterial for targeting and treating inflamed tissues. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-022-00964-5 (2022).
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A biomaterial infused into the bloodstream repairs inflamed tissue. Nat. Biomed. Eng 7, 92–93 (2023). https://doi.org/10.1038/s41551-022-00983-2
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DOI: https://doi.org/10.1038/s41551-022-00983-2
