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Diagnostic imaging

MRI of transmembrane water efflux in gliomas

Water exchange through the transmembrane channel aquaporin-4 can be measured by conventional dynamic-contrast-enhanced magnetic resonance imaging and is a sensitive biomarker of the proliferation of gliomas and their resistance to chemotherapy.

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Fig. 1: Transmembrane water-efflux rates as a biomarker of proliferative glioma.


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Correspondence to Kayvan R. Keshari.

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Competing interests

K.R.K. is co-founder of Atish Technologies and serves on the Scientific Advisory Boards of NVision Imaging Technologies and Imaginostics. He holds patents related to imaging and leveraging cellular metabolism. T.R. declares no competing interests.

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Ruan, T., Keshari, K.R. MRI of transmembrane water efflux in gliomas. Nat. Biomed. Eng (2022).

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