Cytokine receptor agonists can be designed with longer half-lives in circulation and with enhanced penetration of the blood–brain barrier by genetically grafting macrocyclic peptides into the structural loops of fragment crystallizable regions.
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References
Garbers, C., Heink, S., Korn, T. & Rose-John, S. Nat. Rev. Drug Discov. 17, 395–412 (2018).
Silva, A. C. & Lobo, J. M. S. Adv. Biochem. Eng. Biotechnol. 171, 87–113 (2020).
Drucker, D. J. Nat. Rev. Drug Discov. 19, 277–289 (2020).
Vargason, A. M., Anselmo, A. C. & Mitragotri, S. Nat. Biomed. Eng. 5, 951–967 (2021).
Findeisen, M. et al. Nature 574, 63–68 (2019).
Sakai, K. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-022-00955-6 (2022).
Mihara, E. et al. Nat. Commun. 12, 1543 (2021).
Giraldez, M. D., Carneros, D., Garbers, C., Rose-John, S. & Bustos, M. Nat. Rev. Gastroenterol. Hepatol. 18, 787–803 (2021).
Fischer, M. et al. Nat. Biotechnol. 15, 142–145 (1997).
Janda, C. Y. et al. Nature 545, 234–237 (2017).
Wang, C. K. & Craik, D. J. Nat. Chem. Biol. 14, 417–427 (2018).
Dougherty, P. G., Qian, Z. & Pei, D. Biochem. J. 474, 1109–1125 (2017).
Habeshian, S. et al. Nat. Commun. 13, 3823 (2022).
Krammer, C. et al. Chembiochem 22, 1012–1019 (2021).
Acknowledgements
A.K. was supported by the Deutsche Forschungsgemeinschaft (DFG) grants SFB1035-B6 and SFB1123-A3. J.B. received funding from DFG-SFB1123-A3 and by the DFG under Germany’s Excellence Strategy within the framework of the Munich Cluster for Systems Neurology (EXC 2145 SyNergy—ID 390857198).
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A.K. and J.B. are co-inventors on patent applications related to the anti-macrophage migration inhibitory factor and to anti-chemokine strategies in inflammatory and cardiovascular diseases, and on patent applications related to the generation of amyloid-inhibitory peptides.
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Kapurniotu, A., Bernhagen, J. Lasso-grafted designer cytokines. Nat. Biomed. Eng 7, 89–91 (2023). https://doi.org/10.1038/s41551-022-00974-3
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DOI: https://doi.org/10.1038/s41551-022-00974-3