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Protein therapeutics

Lasso-grafted designer cytokines

Cytokine receptor agonists can be designed with longer half-lives in circulation and with enhanced penetration of the blood–brain barrier by genetically grafting macrocyclic peptides into the structural loops of fragment crystallizable regions.

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Fig. 1: Lasso-grafted peptides and antibodies mimicking the properties of the human hepatocyte growth factor.

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Acknowledgements

A.K. was supported by the Deutsche Forschungsgemeinschaft (DFG) grants SFB1035-B6 and SFB1123-A3. J.B. received funding from DFG-SFB1123-A3 and by the DFG under Germany’s Excellence Strategy within the framework of the Munich Cluster for Systems Neurology (EXC 2145 SyNergy—ID 390857198).

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Correspondence to Jürgen Bernhagen.

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A.K. and J.B. are co-inventors on patent applications related to the anti-macrophage migration inhibitory factor and to anti-chemokine strategies in inflammatory and cardiovascular diseases, and on patent applications related to the generation of amyloid-inhibitory peptides.

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Kapurniotu, A., Bernhagen, J. Lasso-grafted designer cytokines. Nat. Biomed. Eng (2022). https://doi.org/10.1038/s41551-022-00974-3

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