Ultrasound pulses have been used to modulate a liver–brain autonomic nerve pathway to prevent or reverse the onset of hyperglycaemia in models of diabetes in several species. The ion channel TRPA1 was shown to be essential in transducing the ultrasound stimuli within the metabolic control circuit.
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Journal of Nanobiotechnology Open Access 07 September 2023
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Cotero, V. et al. Non-invasive sub-organ ultrasound stimulation for targeted neuromodulation. Nat. Commun. 10, 952 (2019). Study showing that ultrasound pulses elicit specific physiological responses from anatomical targets or cultures containing peripheral nerves.
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Zachs, D. P. et al. Noninvasive ultrasound stimulation of the spleen to treat inflammatory arthritis. Nat. Commun. 10, 951 (2019). This paper also shows that whole-organ ultrasound stimulation affects organ-specific functions in a disease model.
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This is a summary of: Cotero, V. et al. Stimulation of the hepatoportal nerve plexus with focused ultrasound restores glucose homoeostasis in diabetic mice, rats and swine. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-022-00870-w (2022).
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Therapeutic ultrasound modulates autonomic nerve pathways in diabetes. Nat. Biomed. Eng 6, 681–682 (2022). https://doi.org/10.1038/s41551-022-00878-2
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