Coating mesenchymal stromal cells with a soft gel incorporating specific chemomechanical cues that enhance the production of collagenases enhances the ability of the cells to inhibit aberrant tissue remodelling in mice with fibrotic lungs.
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Bernardo, M. E. & Fibbe, W. E. Cell Stem Cell 13, 392–402 (2013).
Ankrum, J. & Karp, J. M. Trends Mol. Med. 16, 203–209 (2010).
François, M., Romieu-Mourez, R., Li, M. & Galipeau, J. Mol. Ther. 20, 187–195 (2012).
Boland, L. et al. Mol. Ther. 26, 860–873 (2018).
Levy, O. et al. A Cell Rep. 10, 1261–1268 (2015).
Ranganath, S. H. et al. Stem Cell Rep. 6, 926–939 (2016).
Sun, Y. et al. FASEB J. 25, 1474–1485 (2011).
Yin, J. Q., Zhu, J. & Ankrum, J. A. Nat. Biomed. Eng. 3, 90–104 (2019).
Waterman, R. S., Tomchuck, S. L., Henkle, S. L. & Betancourt, A. M. PLoS ONE 5, e10088 (2010).
Li, C. X. et al. Nat. Mater. 16, 379–389 (2017).
Wong, S. W. et al. Nat. Biomed Eng. https://doi.org/10.1038/s41551-021-00740-x (2021).
Ankrum, J. A., Dastidar, R. G., Ong, J. F., Levy, O. & Karp, J. M. Sci. Rep. 4, 4645 (2014).
Krampera, M. Leukemia 25, 1408–1414 (2011).
Murphy, W. L., McDevitt, T. C. & Engler, A. J. Nat. Mater. 13, 547–557 (2014).
Caplan, A. I. & Correa, D. Cell Stem Cell 9, 11–15 (2011).
The authors declare no competing interests.
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Schrodt, M.V., Ankrum, J.A. Chemomechanically antifibrotic stromal cells. Nat Biomed Eng 6, 6–7 (2022). https://doi.org/10.1038/s41551-021-00840-8