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Chemomechanically antifibrotic stromal cells

Coating mesenchymal stromal cells with a soft gel incorporating specific chemomechanical cues that enhance the production of collagenases enhances the ability of the cells to inhibit aberrant tissue remodelling in mice with fibrotic lungs.

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Fig. 1: MSCs modulate their antifibrotic behaviour in response to chemical and mechanical cues.


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Correspondence to James A. Ankrum.

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Schrodt, M.V., Ankrum, J.A. Chemomechanically antifibrotic stromal cells. Nat Biomed Eng 6, 6–7 (2022).

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