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XENO-ORGAN TRANSPLANTATION

Extensively edited pigs

By using CRISPR and transposon constructs, pigs have been genetically modified to inactivate endogenous retroviruses and to enhance the compatibility of their organs with the human immune and coagulation systems.

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Fig. 1: Pigs for xeno-organ transplantation.

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Correspondence to Angelika Schnieke.

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Fischer, K., Schnieke, A. Extensively edited pigs. Nat Biomed Eng 5, 128–129 (2021). https://doi.org/10.1038/s41551-021-00684-2

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