Lipofuscin, an endogenous pigment, can be used as a near-infrared fluorescent biomarker to stage and to monitor the progression of chronic liver disease, as shown in mice with induced liver disease and in human livers biopsied from patients with liver fibrosis.
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O’Sullivan, J.J., Harder, N.H.O. & Heffern, M.C. Detecting liver disease via an endogenous pigment. Nat Biomed Eng 4, 761–762 (2020). https://doi.org/10.1038/s41551-020-0601-2