Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

BRAIN–COMPUTER INTERFACES

From unstable input to robust output

In the presence of recording instabilities, the performance of brain–computer interfaces can be robustly maintained by exploiting ‘hidden’ structures underlying neural activity.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Patterns in the underlying activity of simultaneously recorded neurons can be leveraged to improve the robustness of decoders for BCIs.

References

  1. Pandarinath, C. et al. eLife 6, 18554 (2017).

    Article  Google Scholar 

  2. Collinger, J. L. et al. Lancet 381, 557–564 (2013).

    Article  Google Scholar 

  3. Anumanchipalli, G. K., Chartier, J. & Chang, E. F. Nature 568, 493–498 (2019).

    Article  CAS  Google Scholar 

  4. Ajiboye, A. B. et al. Lancet 389, 1821–1830 (2017).

    Article  Google Scholar 

  5. Sussillo, D., Stavisky, S. D., Kao, J. C., Ryu, S. I. & Shenoy, K. V. Nat. Commun. 7, 13749 (2016).

    Article  CAS  Google Scholar 

  6. Downey, J. E., Schwed, N., Chase, S. M., Schwartz, A. B. & Collinger, J. L. J. Neural Eng. 15, 046016 (2018).

    Article  Google Scholar 

  7. Degenhart, A. D. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-020-0542-9 (2020).

  8. Gallego, J. A., Perich, M. G., Miller, L. E. & Solla, S. A. Neuron 94, 978–984 (2017).

    Article  CAS  Google Scholar 

  9. Sadtler, P. T. et al. Nature 512, 423–426 (2014).

    Article  CAS  Google Scholar 

  10. Kao, J. C., Ryu, S. I. & Shenoy, K. V. Sci. Rep. 7, 7395 (2017).

    Article  Google Scholar 

  11. Dyer, E. L. et al. Nat. Biomed. Eng. 1, 967–976 (2017).

    Article  Google Scholar 

  12. Pandarinath, C. et al. Nat. Meth. 15, 805–815 (2018).

    Article  CAS  Google Scholar 

  13. Farshchian, A. et al. In International Conference on Learning Representations (OpenReview.net, 2019).

  14. Gallego, J. A., Perich, M. G., Chowdhury, R. H., Solla, S. A. & Miller, L. E. Nat. Neurosci. 23, 260–270 (2020).

    Article  CAS  Google Scholar 

  15. Jarosiewicz, B. et al. Sci. Transl. Med. 7, 313ra179 (2015).

    Article  Google Scholar 

  16. Oby, E. R. et al. Proc. Natl Acad. Sci. USA 116, 15210–15215 (2019).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Chethan Pandarinath.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wimalasena, L.N., Miller, L.E. & Pandarinath, C. From unstable input to robust output. Nat Biomed Eng 4, 665–667 (2020). https://doi.org/10.1038/s41551-020-0587-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41551-020-0587-9

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing