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An in vitro model of myocardial infarction

Structural and functional changes following infarction in a human heart can be modelled with human cardiac organoids set in a hypoxic gradient and stimulated with the neurotransmitter noradrenaline.

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Fig. 1: Human cardiac organoids as models of myocardial infarction.


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Correspondence to James Hudson.

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Competing interests

R.M. and J.H. have collaborated with AstraZeneca for the discovery of new heart-failure drugs, are on the scientific advisory board of Dynomics for the discovery of new heart-failure drugs, and have patents related to bioengineered-tissue technologies and culture conditions, and to putative therapeutic targets for heart failure.

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Mills, R., Hudson, J. An in vitro model of myocardial infarction. Nat Biomed Eng 4, 366–367 (2020).

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