Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Resolving nanoscale strains in whole joints

Nanoscale strains in the intact whole joints of young, old and osteoarthritic mice can be resolved ex vivo via synchrotron X-ray tomography when combined with nanometrically precise mechanical loading.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: Maps of nanoscale strains in intact murine knee joints obtained by sCT and DVC.


  1. 1.

    Burr, D. B. & Gallant, M. A. Nat. Rev. Rheumatol. 8, 665–673 (2012).

    CAS  Article  Google Scholar 

  2. 2.

    Robinson, D. et al. J. Mech. Behav. Biomed. Mater. 61, 96–109 (2016).

    CAS  Article  Google Scholar 

  3. 3.

    Smith, C. R. et al. J. Knee Surg. 29, 99–106 (2015).

    Article  Google Scholar 

  4. 4.

    Kersh, M. E. et al. J. Bone Miner. Res. 33, 1999–2006 (2018).

    Article  Google Scholar 

  5. 5.

    Dall’Ara, E., Barber, D. & Viceconti, M. J. Biomech. 47, 2956–2963 (2014).

    Article  Google Scholar 

  6. 6.

    Kamel, M. et al. Nat. Biomed. Eng. (2019).

    Article  Google Scholar 

  7. 7.

    Bakalova, L. P. et al. J. Bone Miner. Res. 32, 186–187 (2017).

    Google Scholar 

  8. 8.

    Kersh, M. E. et al. J. Bone Miner. Res. 28, 1022–1028 (2013).

    Article  Google Scholar 

  9. 9.

    Song, H., Polk, J. D. & Kersh, M. E. J. Exp. Biol. 222, 203554 (2019).

    Article  Google Scholar 

  10. 10.

    Lin, Y. C., Walter, J. P. & Pandy, M. G. Ann. Biomed. Eng. 46, 1216–1227 (2018).

    Article  Google Scholar 

  11. 11.

    Jackman, T. M. et al. J. Biomechanics 49, 267–275 (2016).

    Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Mariana E. Kersh.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Kersh, M.E. Resolving nanoscale strains in whole joints. Nat Biomed Eng 4, 257–258 (2020).

Download citation


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing