Nanoscale strains in the intact whole joints of young, old and osteoarthritic mice can be resolved ex vivo via synchrotron X-ray tomography when combined with nanometrically precise mechanical loading.
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Burr, D. B. & Gallant, M. A. Nat. Rev. Rheumatol. 8, 665–673 (2012).
Robinson, D. et al. J. Mech. Behav. Biomed. Mater. 61, 96–109 (2016).
Smith, C. R. et al. J. Knee Surg. 29, 99–106 (2015).
Kersh, M. E. et al. J. Bone Miner. Res. 33, 1999–2006 (2018).
Dall’Ara, E., Barber, D. & Viceconti, M. J. Biomech. 47, 2956–2963 (2014).
Kamel, M. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-019-0477-1 (2019).
Bakalova, L. P. et al. J. Bone Miner. Res. 32, 186–187 (2017).
Kersh, M. E. et al. J. Bone Miner. Res. 28, 1022–1028 (2013).
Song, H., Polk, J. D. & Kersh, M. E. J. Exp. Biol. 222, 203554 (2019).
Lin, Y. C., Walter, J. P. & Pandy, M. G. Ann. Biomed. Eng. 46, 1216–1227 (2018).
Jackman, T. M. et al. J. Biomechanics 49, 267–275 (2016).
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Kersh, M.E. Resolving nanoscale strains in whole joints. Nat Biomed Eng 4, 257–258 (2020). https://doi.org/10.1038/s41551-020-0531-z