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Sensitive sensing of biomarkers in interstitial fluid

A minimally invasive microneedle patch detects specific protein biomarkers in dermal interstitial fluid at high sensitivity via a needle-integrated immunoassay coupled with an ultrabright fluorescent label.

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Fig. 1: Microneedle patch for the detection of biomarkers in ISF.
Fig. 2: Strategies for the sampling of biomarkers in ISF.


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Correspondence to Mark R. Prausnitz.

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Competing interests

M.R.P. is an inventor of patents licensed to companies developing microneedle-based products, a paid advisor to companies developing microneedle-based products, and a founder or shareholder of companies developing microneedle-based products (Micron Biomedical). These potential competing interests have been disclosed and are managed by Georgia Tech.

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Kim, Y., Prausnitz, M.R. Sensitive sensing of biomarkers in interstitial fluid. Nat Biomed Eng 5, 3–5 (2021).

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