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CANCER MECHANOBIOLOGY

Epigenetic regulation of mechanotransduction

Nature Biomedical Engineering volume 5, pages 8–10 (2021)Cite this article

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The DNA methylation of the promoter region of the oncogenic Yes-associated protein is reversibly regulated by the stiffness of the extracellular matrix.

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Fig. 1: Mechanisms of mechanotransduction and the role of the epigenome.

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Authors and Affiliations

  1. Department of Mechanical Engineering, Santa Barbara, CA, USA

    Ryan Stowers

  2. Center for Bioengineering, University of California, Santa Barbara, Santa Barbara, CA, USA

    Ryan Stowers

  3. Department of Mechanical Engineering, Stanford University, Stanford, CA, USA

    Ovijit Chaudhuri

Authors
  1. Ryan Stowers
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  2. Ovijit Chaudhuri
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Correspondence to Ryan Stowers or Ovijit Chaudhuri.

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The authors declare no competing interests.

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Stowers, R., Chaudhuri, O. Epigenetic regulation of mechanotransduction. Nat Biomed Eng 5, 8–10 (2021). https://doi.org/10.1038/s41551-020-00678-6

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