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Swaying leukocyte traffic from the bone marrow

Systemically injected lipid–polymer nanoparticles delivering small interfering RNAs into bone-marrow endothelium modulate leukocyte trafficking from the bone marrow to the blood.

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Fig. 1: Nanoparticles for the delivery of siRNA to bone-marrow endothelium.

References

  1. Petit, I. et al. Nat. Immunol. 3, 687–694 (2002).

    Article  CAS  PubMed  Google Scholar 

  2. Hattori, K. et al. Blood 97, 3354–3360 (2001).

    Article  CAS  PubMed  Google Scholar 

  3. Serbina, N. V. & Pamer, E. G. Nat. Immunol. 7, 311–317 (2006).

    Article  CAS  PubMed  Google Scholar 

  4. Charo, I. F. & Ransohoff, R. M. N. Engl. J. Med. 354, 610–621 (2006).

    Article  CAS  PubMed  Google Scholar 

  5. Krohn-Grimberghe, M. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-020-00623-7 (2020).

  6. Dahlman, J. E. et al. Nat. Nanotechnol. 9, 648–655 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Weissleder, R. et al. Nat. Mater. 13, 125–138 (2014).

    Article  CAS  PubMed  Google Scholar 

  8. Larochelle, A. et al. Blood 107, 3772–3778 (2006).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Askari, A. T. et al. Lancet 362, 697–703 (2003).

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Patrick C. H. Hsieh.

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Prajnamitra, R.P., Chen, HC. & Hsieh, P.C.H. Swaying leukocyte traffic from the bone marrow. Nat Biomed Eng 4, 1026–1027 (2020). https://doi.org/10.1038/s41551-020-00647-z

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