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Multifunctional optofluidic brain probes

Smartphone-controlled optofluidic neural implants with replaceable and replenishable plug-like drug cartridges enable the selective wireless manipulation of brain circuits in rodents via chronic pharmacology and photostimulation.

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Fig. 1: Refillable optofluidic brain implants for neuromodulation.
Fig. 2: Potential integration of optofluidic brain probes and other diagnostic and drug-delivery systems.


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Correspondence to John F. Zimmerman or Bozhi Tian.

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Zimmerman, J.F., Tian, B. Multifunctional optofluidic brain probes. Nat Biomed Eng 3, 596–597 (2019).

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