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MICROPHYSIOLOGICAL SYSTEMS

Human-gut-microbiome on a chip

A microfluidic chip incorporating oxygen gradients, a diverse human microbiota and patient-derived cells, mimics interactions between microorganisms and host tissue in the human gut.

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References

  1. 1.

    Dave, M. et al. Transl. Res. 160, 246–257 (2012).

  2. 2.

    Halfvarson, J. et al. Nat. Microbiol. 2, 1–7 (2017).

  3. 3.

    Dejea, C. M. et al. Science. 359, 592–597 (2018).

  4. 4.

    Kostic, A. D. et al. Genes Dev. 27, 701–718 (2013).

  5. 5.

    Seoka, J. et al. Proc. Natl Acad. Sci. USA 110, 3507–3512 (2013).

  6. 6.

    Kim, H. J. et al. Proc. Natl Acad. Sci. USA 113, E7–E15 (2016).

  7. 7.

    Jalili-Firoozinezhad, S. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-019-0397-0 (2019).

  8. 8.

    Pompano, R. R. et al. Annu. Rev. Biochem. 86, 333–356 (2017).

  9. 9.

    Begley, M. et al. FEMS Microbiol. Rev. 29, 625–651 (2005).

  10. 10.

    Parks, D. J. et al. Science 284, 1365–1368 (1999).

  11. 11.

    Goodwin, B. et al. Mol. Cell 6, 517–526 (2000).

  12. 12.

    Ma, L. et al. Proc. Natl Acad. Sci. USA 111, 9768–9773 (2014).

  13. 13.

    Yasuda, K. et al. Cell Host Microbe 17, 385–391 (2015).

  14. 14.

    Earle, K. A. et al. Cell Host Microbe 18, 478–488 (2015).

  15. 15.

    Morgan, X. C. et al. mBio 3, e00116–12 (2012).

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Correspondence to Rustem F. Ismagilov.

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Fig. 1: Human-gut-microbiome on a chip.