Plasmids coding for a toxin gene that is only expressed in the presence of a virulence-associated transcription factor lead to the killing of only the virulent form of the bacterium Vibrio cholerae in a mixed bacterial population.
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References
Lee Ventola, C. Pharmacol. Therapeut. 40, 277–283 (2015).
Ram, G., Ross, H. F., Novick, R. P., Rodriguez-Pagan, I. & Jiang, D. Nat. Biotechnol. 36, 971–976 (2018).
Mayville, P. et al. Proc. Natl Acad. Sci. USA 96, 1218–1223 (1999).
Bikard, D. et al. Nat. Biotechnol. 32, 1146–1150 (2014).
Citorik, R. J., Mimee, M. & Lu, T. K. Nat. Biotechnol. 32, 1141–1145 (2014).
Lopez-Igual, R., Bernal-Bayard, J., Rodriguez-Paton, A., Ghigo, J. M. & Mazel, D. Nat. Biotechnol. https://doi.org/10.1038/s41587-019-0105-3 (2019).
Wu, H., Hu, Z. & Liu, X. Q. Proc. Natl Acad. Sci. USA 95, 9226–9231 (1998).
Schmid-Hempel, P. & Frank, S. A. PLoS Pathog. 3, 1372–1373 (2007).
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The author is a co-inventor on a patent application for a non-antibiotic method of treating bacterial infections.
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Novick, R. Targeted killing of virulent Vibrio cholerae. Nat Biomed Eng 3, 507–508 (2019). https://doi.org/10.1038/s41551-019-0419-y
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DOI: https://doi.org/10.1038/s41551-019-0419-y
