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Neuroethical considerations of high-density electrode arrays

Nature Biomedical Engineering volume 3, pages 586–589 (2019)Cite this article

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The development of implantable electrode arrays that broadly and seamlessly integrate with brain tissue will require innovation that responsibly considers clinically relevant neuroethical concerns.

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Fig. 1: Summary of issues associated with traditional arrays, and considerations for high-density, next-generation arrays.

References

  1. Bergey, G. K. et al. Neurology 84, 810–817 (2015).

    Article  CAS  Google Scholar 

  2. Salatino, J. W., Ludwig, K. A., Kozai, T. D. & Purcell, E. K. Nat. Biomed. Eng. 1, 862–877 (2017).

    Article  CAS  Google Scholar 

  3. Biran, R., Martin, D. C. & Tresco, P. A. Exp. Neurol. 195, 115–126 (2005).

    Article  CAS  Google Scholar 

  4. Eles, J. R., Vazquez, A. L., Kozai, T. D. & Cui, X. T. Biomaterials 174, 79–94 (2018).

    Article  CAS  Google Scholar 

  5. Salatino, J. W., Winter, B. M., Drazin, M. H. & Purcell, E. K. J. Neurophysiol. 118, 194–202 (2017).

    Article  CAS  Google Scholar 

  6. Salatino, J. W., Kale, A. P. & Purcell, E. K. bioRxiv https://doi.org/10.1101/518811 (2019).

  7. Thompson, C. H., Zoratti, M. J., Langhals, N. B. & Purcell, E. K. Tissue Eng. Pt B Rev. 22, 125–135 (2015).

    Article  Google Scholar 

  8. Winter, B., Daniels, S., Salatino, J. & Purcell, E. Micromachines 9, 476 (2018).

    Article  Google Scholar 

  9. Kozai, T. D. et al. Nat. Mater. 11, 1065–1073 (2012).

    Article  CAS  Google Scholar 

  10. Jun, J. J. et al. Nature 551, 232–236 (2017).

    Article  CAS  Google Scholar 

  11. Chen, R., Canales, A. & Anikeeva, P. Nat. Rev. Mater. 2, 16093 (2017).

    Article  CAS  Google Scholar 

  12. Rodger, D. C. et al. Sens. Actuators B 132, 449–460 (2008).

    Article  CAS  Google Scholar 

  13. Liu, J. et al. Nat. Nanotech. 10, 629–636 (2015).

    Article  CAS  Google Scholar 

  14. Kim, D. H. et al. Science 320, 507–511 (2008).

    Article  CAS  Google Scholar 

  15. Vera, J. & Martínez-Sánchez, F. Span. J. Psychol. 19, E1 (2016).

    Article  Google Scholar 

  16. Lipsman, N. & Glannon, W. Bioethics 27, 465–470 (2012).

    Article  Google Scholar 

  17. de Haan, S., Rietveld, E., Stokhof, M. & Denys, D. PLoS ONE 12, e0175748 (2017).

    Article  Google Scholar 

  18. Goering, S., Klein, E., Dougherty, D. D. & Widge, A. S. AJOB Neurosci. 8, 59–70 (2017).

    Article  Google Scholar 

  19. Gilbert, F. AJOB Neurosci. 6, 4–11 (2015).

    Article  Google Scholar 

  20. Kraemer, F. Neuroethics 6, 483–497 (2011).

    Article  Google Scholar 

  21. Yuste, R. et al. Nature 551, 159–163 (2017).

    Article  CAS  Google Scholar 

  22. Clausen, J. et al. Science 356, 1338–1339 (2017).

    Article  CAS  Google Scholar 

  23. Chhatbar, P. & Saha, S. J. Long Term Eff. Med. Implants 19, 123–127 (2009).

    Article  Google Scholar 

  24. Greely, H. T. et al. J. Neurosci. 38, 10586–10588 (2018).

    Article  CAS  Google Scholar 

  25. Van Gompel, J. J. J. Neurosurg. 25, E23 (2008).

    Google Scholar 

  26. Ramos, K. M. et al. Neuron 101, 394–398 (2019).

    Article  CAS  Google Scholar 

  27. Chiong, W., Leonard, M. K. & Chang, E. F. Neurosurg. 6, 35 (2017).

    Google Scholar 

  28. Pycroft, L. et al. World Neurosurg. 92, 454–462 (2016).

    Article  Google Scholar 

  29. Lacoste, A., Berenshteyn, F. & Brivanlou, A. H. Cell Stem Cell 5, 332–342 (2009).

    Article  CAS  Google Scholar 

  30. Seo, D. et al. Neuron 91, 529–539 (2016).

    Article  CAS  Google Scholar 

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Acknowledgements

The authors thank K. Ludwig for his helpful feedback during the preparation of early drafts of this manuscript.

Author information

Authors and Affiliations

  1. Center for Ethics and Humanities in the Life Sciences, Michigan State University, East Lansing, MI, USA

    Laura Cabrera

  2. Department of Translational Science and Molecular Medicine, Michigan State University, East Lansing, MI, USA

    Laura Cabrera

  3. Michigan State University, East Lansing, MI, USA

    Charles Sadle

  4. Department of Biomedical Engineering, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA

    Erin Purcell

  5. Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI, USA

    Erin Purcell

Authors
  1. Laura Cabrera
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  2. Charles Sadle
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  3. Erin Purcell
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Correspondence to Laura Cabrera.

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The authors declare no competing interests.

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Cabrera, L., Sadle, C. & Purcell, E. Neuroethical considerations of high-density electrode arrays. Nat Biomed Eng 3, 586–589 (2019). https://doi.org/10.1038/s41551-019-0407-2

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