The oxygen consumption rates of single tumour cells can be measured via photoacoustic microscopy, by leveraging haemoglobin as both an oxygen supplier and an oxygen sensor.
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Walsh, A.J., Sharick, J.T. & Skala, M.C. Imaging intratumoral metabolic heterogeneity. Nat Biomed Eng 3, 333–334 (2019). https://doi.org/10.1038/s41551-019-0398-z
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DOI: https://doi.org/10.1038/s41551-019-0398-z