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Urinary nanosensors of early transplant rejection

Nanoparticle sensors of the activity of the protease granzyme B detect early T-cell-mediated rejection of transplanted skin grafts in mice via the release of a proteolytically cleaved fluorescence reporter that filters into urine.

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Fig. 1: Nanosensors for detecting acute T-cell-mediated transplant rejection.


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Correspondence to Anita S. Chong.

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Chong, A.S. Urinary nanosensors of early transplant rejection. Nat Biomed Eng 3, 251–252 (2019).

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