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NANOMEDICINE

Urinary nanosensors of early transplant rejection

Nanoparticle sensors of the activity of the protease granzyme B detect early T-cell-mediated rejection of transplanted skin grafts in mice via the release of a proteolytically cleaved fluorescence reporter that filters into urine.

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Fig. 1: Nanosensors for detecting acute T-cell-mediated transplant rejection.

References

  1. 1.

    Merrill, J. P., Murray, J. E., Harrison, J. H. & Guild, W. R. J. Am. Med. Assoc. 160, 277–282 (1956).

    CAS  Article  Google Scholar 

  2. 2.

    Roberts, D. M., Jiang, S. H. & Chadban, S. J. Transplantation 94, 775–783 (2012).

    CAS  Article  Google Scholar 

  3. 3.

    Hara, S. Nephrology 23, 45–51 (2018).

    Article  Google Scholar 

  4. 4.

    Nissaisorakarn, V., Lee, J. R., Lubetzky, M. & Suthanthiran, M. Hum. Immunol. 79, 343–355 (2018).

    CAS  Article  Google Scholar 

  5. 5.

    Kummer, J. A. et al. Kidney Int. 47, 70–77 (1995).

    CAS  Article  Google Scholar 

  6. 6.

    Mac, Q. D. et al. Nat. Biomed.Eng. https://doi.org/10.1038/s41551-019-0358-7 (2019).

    Article  Google Scholar 

  7. 7.

    Kataoka, T. & Nagai, K. Immunol. Lett. 72, 49–52 (2000).

    CAS  Article  Google Scholar 

  8. 8.

    Venner, J. M. et al. Am. J. Transplant. 14, 2565–2576 (2014).

    CAS  Article  Google Scholar 

  9. 9.

    Litjens, N. H. R. et al. Front. Immunol. 8, 1137 (2017).

    Article  Google Scholar 

  10. 10.

    Leboeuf, C. et al. Am. J. Transplant. 17, 2591–2600 (2017).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Anita S. Chong.

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Chong, A.S. Urinary nanosensors of early transplant rejection. Nat Biomed Eng 3, 251–252 (2019). https://doi.org/10.1038/s41551-019-0389-0

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