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IMMUNOTHERAPY

A PD-1-specific toxin suppresses autoimmunity

Nature Biomedical Engineering volume 3, pages 253–254 (2019)Cite this article

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Depletion of cells expressing the cell-membrane protein programmed cell-death protein-1 using an antibody-based toxin delays the onset of disease in a mouse model of diabetes and reverses paralysis in mice with experimental autoimmune encephalomyelitis, without compromising physiological immunity.

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Fig. 1: Amelioration of mouse models of autoimmunity via the depletion of PD-1-expressing cells mediated by the αPD-1–ABD–PE immunotoxin.

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Authors and Affiliations

  1. Plastic & Reconstructive Surgery and Transplant Surgery Divisions, Department of Surgery, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

    Zhirui Wang & Christene A. Huang

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  1. Zhirui Wang
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  2. Christene A. Huang
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Correspondence to Zhirui Wang.

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Wang, Z., Huang, C.A. A PD-1-specific toxin suppresses autoimmunity. Nat Biomed Eng 3, 253–254 (2019). https://doi.org/10.1038/s41551-019-0384-5

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