Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:


A designer chaperone against prion diseases

A computationally designed small molecule inhibits the replication of prion-protein aggregates and ameliorates neurological symptoms in mouse and non-human-primate models of transmissible spongiform encephalopathy.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Experimental workflow for the identification and characterization of an anti-prion-protein pharmacological chaperone.


  1. Prusiner, S. B. Annu. Rev. Genet. 47, 601–623 (2013).

    Article  CAS  Google Scholar 

  2. Prusiner, S. B. Science 216, 136–144 (1982).

    Article  CAS  Google Scholar 

  3. Chiti, F. & Dobson, C. M. Annu. Rev. Biochem. 75, 333–366 (2006).

    Article  CAS  Google Scholar 

  4. Pocchiari, M. et al. Brain 127, 2348–2359 (2004).

    Article  CAS  Google Scholar 

  5. Giles, K., Olson, S. H. & Prusiner, S. B. Cold Spring Harb. Perspect Med. 7, a023747 (2017).

  6. Soto, C. & Pritzkow, S. Nat. Neurosci. 21, 1332–1340 (2018).

    Article  CAS  Google Scholar 

  7. Barreca, M. L., Iraci, N., Biggi, S., Cecchetti, V. & Biasini, E. Pathogens 7, E27 (2018).

  8. Yamaguchi, K. et al. Nat. Biomed. Eng. (2019).

  9. Kuwata, K. et al. Proc. Natl Acad. Sci. USA 104, 11921–11926 (2007).

    Article  CAS  Google Scholar 

  10. Ma, B., Yamaguchi, K., Fukuoka, M. & Kuwata, K. Biochem. Biophys. Res. Commun. 469, 930–935 (2016).

    Article  CAS  Google Scholar 

  11. Wilham, J. M. et al. PLoS Pathog. 6, e1001217 (2010).

    Article  Google Scholar 

  12. Saborio, G. P., Permanne, B. & Soto, C. Nature 411, 810–813 (2001).

    Article  CAS  Google Scholar 

  13. Tamguney, G. et al. J. Gen. Virol. 89, 1777–1788 (2008).

    Article  CAS  Google Scholar 

  14. Scott, S. et al. Amyotroph. Lateral Scler. 9, 4–15 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Emiliano Biasini.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Biasini, E. A designer chaperone against prion diseases. Nat Biomed Eng 3, 167–168 (2019).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing