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Local magnetic activation of CRISPR

Magnetic nanoparticles complexed with recombinant baculoviral vectors containing the CRISPR–Cas9 machinery enable the local magnetic activation of genome editing.

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Fig. 1: Spatial control of CRISPR–Cas9 genome editing via a nanomagnet.


  1. Komor, A. C., Badran, A. H. & Liu, D. R. Cell 168, 20–36 (2017).

    CAS  Article  Google Scholar 

  2. Ran, F. A. et al. Nature 520, 186–191 (2015).

    CAS  Article  Google Scholar 

  3. Chew, W. L. et al. Nat. Meth. 13, 868–874 (2016).

    CAS  Article  Google Scholar 

  4. Charlesworth, C. T. et al. Preprint at bioRxiv (2018).

  5. Chen, X. & Goncalves, M. A. F. V. Mol. Ther. 24, 447–457 (2016).

    CAS  Article  Google Scholar 

  6. Zhu, H. et al. Nat. Biomed. Eng. (2019).

  7. Airenne, K. J. et al. Mol. Ther. 21, 739–749 (2013).

    CAS  Article  Google Scholar 

  8. Lin, M.-W. et al. Nucleic Acid. Res. 46, e93–e93 (2018).

    Article  Google Scholar 

  9. Sung, L.-Y. et al. Nat. Protoc. 9, 1882–1899 (2014).

    CAS  Article  Google Scholar 

  10. Lin, C.-Y. et al. Biomaterials 34, 9401–9412 (2013).

    CAS  Article  Google Scholar 

  11. Huser, A., Rudolph, M. & Hofmann, C. Nat. Biotechnol. 19, 451–455 (2001).

    CAS  Article  Google Scholar 

  12. Hwang, J. H. et al. Int. J. Pharm. 421, 397–404 (2011).

    CAS  Article  Google Scholar 

  13. Heun, Y. et al. Theranostics 7, 295–307 (2017).

    CAS  Article  Google Scholar 

  14. Nihongaki, Y., Kawano, F., Nakajima, T. & Sato, M. Nat. Biotechnol. 33, 755–760 (2015).

    CAS  Article  Google Scholar 

  15. Chen, C.-Y. et al. Mol. Pharmaceut. 8, 1505–1514 (2011).

    CAS  Article  Google Scholar 

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Correspondence to Yu-Chen Hu.

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Hsu, MN., Hu, YC. Local magnetic activation of CRISPR. Nat Biomed Eng 3, 83–84 (2019).

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