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GENOME EDITING

Complex heritability in cardiomyopathy

Human cardiomyocytes and mice edited to harbour gene variants found in patients with dilated cardiomyopathy reveal combinatorial genetic interactions that contribute to the complex genetic heritability of the disease.

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Fig. 1: Genome-edited cardiomyocytes and mouse models for studying the genetic basis of cardiovascular diseases.

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Correspondence to Joseph C. Wu.

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Ma, N., Zhang, S.L. & Wu, J.C. Complex heritability in cardiomyopathy. Nat Biomed Eng 3, 87–89 (2019). https://doi.org/10.1038/s41551-019-0353-z

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