Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Artefact-free wireless closed-loop device

A miniaturized 128-electrode brain implant enables wireless closed-loop neuromodulation with artefact cancellation in a non-human primate.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: Artefact-free closed-loop neuromodulation.


  1. 1.

    Hariz, G.-M., Limousin, P. & Hamberg, K. J. Parkinsons. Dis. 6, 335–347 (2016).

    Article  Google Scholar 

  2. 2.

    Little, S. et al. Ann. Neurol. 74, 449–57 (2013).

    Article  Google Scholar 

  3. 3.

    Rossi, L. et al. J. Neural Eng. 4, 96–106 (2007).

    CAS  Article  Google Scholar 

  4. 4.

    Rouse, A. G. et al. J. Neural Eng. 8, 036018 (2011).

    CAS  Article  Google Scholar 

  5. 5.

    Zhou, A. Nat. Biomed. Eng. (2018).

  6. 6.

    Viventi, J. et al. Nat. Neurosci. 14, 1599–605 (2011).

    CAS  Article  Google Scholar 

  7. 7.

    Tsai, D., Sawyer, D., Bradd, A., Yuste, R. & Shepard, K. L. Nat. Commun. 8, 1802 (2017).

    Article  Google Scholar 

  8. 8.

    Jun, J. J. et al. Nature 551, 232–236 (2017).

    CAS  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Jonathan Viventi.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Chiang, CH., Viventi, J. Artefact-free wireless closed-loop device. Nat Biomed Eng 3, 3–4 (2019).

Download citation


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing