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Machine learning finds Cas9-edited genotypes

A machine-learning algorithm reliably predicts Cas9-edited genotypes arising from the repair of DNA double-strand breaks in mouse cells and human cells.

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Fig. 1: The major editing outcomes after Cas9-mediated DNA cleavage can be predicted by machine learning.


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Correspondence to Jin-Soo Kim.

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Competing interests

J.-S.K. is a co-founder of and holds stock in ToolGen, Inc., a company focused on therapeutic genome editing.

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Bae, S., Kim, JS. Machine learning finds Cas9-edited genotypes. Nat Biomed Eng 2, 892–893 (2018).

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