A machine-learning algorithm reliably predicts Cas9-edited genotypes arising from the repair of DNA double-strand breaks in mouse cells and human cells.
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References
Koike-Yusa, H. et al. Nat. Biotechnol. 32, 267–273 (2013).
van Overbeek, M. et al. Mol. Cell 63, 633–646 (2016).
Bae, S., Kweon, J., Kim, H. S. & Kim, J.-S. Nat. Methods 11, 705–706 (2014).
Shen, M. W. et al. Nature https://doi.org/10.1038/s41586-018-0686-x (2018).
Kim, H. K. et al. Nat. Biotechnol. 36, 239–241 (2018).
Kosicki, M., Tomberg, K. & Bradley, A. R. Nat. Biotechnol. 36, 765–771 (2018).
Ma, H. et al. Nature 548, 413–419 (2017).
Park, C.-Y. et al. Cell Stem Cell 17, 213–220 (2015).
Komor, A. C. et al. Nature 533, 420–424 (2016).
Gaudelli, N. M. et al. Nature 551, 464–471 (2017).
Nishida, K. et al. Science 353, aaf8729 (2016).
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J.-S.K. is a co-founder of and holds stock in ToolGen, Inc., a company focused on therapeutic genome editing.
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Bae, S., Kim, JS. Machine learning finds Cas9-edited genotypes. Nat Biomed Eng 2, 892–893 (2018). https://doi.org/10.1038/s41551-018-0327-6
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DOI: https://doi.org/10.1038/s41551-018-0327-6
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