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Engineered niches model the onset of metastasis

A humanized biomaterial microenvironment that mimics the pre-metastatic niche captures disseminated tumour cells and recapitulates metastatic progression after implantation in xenografted mice.

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Fig. 1: Implantable humanized pre-metastatic niches for modelling disseminated tumour-cell seeding and metastatic progression.


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Correspondence to Irina Matei or David Lyden.

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Matei, I., Rampersaud, S. & Lyden, D. Engineered niches model the onset of metastasis. Nat Biomed Eng 2, 885–887 (2018).

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