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Engineered niches model the onset of metastasis

A humanized biomaterial microenvironment that mimics the pre-metastatic niche captures disseminated tumour cells and recapitulates metastatic progression after implantation in xenografted mice.

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Fig. 1: Implantable humanized pre-metastatic niches for modelling disseminated tumour-cell seeding and metastatic progression.


  1. 1.

    Steeg, P. S. Nat. Rev. Cancer 16, 201–218 (2016).

    CAS  Article  Google Scholar 

  2. 2.

    Peinado, H. et al. Nat. Rev. Cancer 17, 302–317 (2017).

    CAS  Article  Google Scholar 

  3. 3.

    Sosa, M. S., Bragado, P. & Aguirre-Ghiso, J. A. Nat. Rev. Cancer 14, 611–622 (2014).

    CAS  Article  Google Scholar 

  4. 4.

    Ghajar, C. M. et al. Nat. Cell Biol. 15, 807–817 (2013).

    CAS  Article  Google Scholar 

  5. 5.

    Aguado, B. A., Bushnell, G. G., Rao, S. S., Jeruss, J. S. & Shea, L. D. Nat. Biomed. Eng. 1, 0077 (2017).

    Article  Google Scholar 

  6. 6.

    Mohme, M., Riethdorf, S. & Pantel, K. Nat. Rev. Clin. Oncol. 14, 155–167 (2017).

    CAS  Article  Google Scholar 

  7. 7.

    Gu, L. & Mooney, D. J. Nat. Rev. Cancer 16, 56–66 (2016).

    CAS  Article  Google Scholar 

  8. 8.

    Wang, F. et al. Proc. Natl Acad. Sci. USA 95, 14821–14826 (1998).

    CAS  Article  Google Scholar 

  9. 9.

    Carpenter, R. A., Kwak, J.-G., Peyton, S. R. & Lee, J. Nat. Biomed. Eng. (2018).

    Article  Google Scholar 

  10. 10.

    Chung, K. et al. Nature 497, 332–337 (2013).

    CAS  Article  Google Scholar 

  11. 11.

    Rao, S. S. et al. Cancer Res. 76, 5209–5218 (2016).

    CAS  Article  Google Scholar 

  12. 12.

    Azarin, S. M. et al. Nat. Commun. 6, 8094 (2015).

    Article  Google Scholar 

  13. 13.

    Vermesh, O. et al. Nat. Biomed. Eng. 2, 696–705 (2018).

    Article  Google Scholar 

  14. 14.

    Kang, Y. & Pantel, K. Cancer Cell 23, 573–581 (2013).

    CAS  Article  Google Scholar 

  15. 15.

    Oudin, M. J. & Weaver, V. M. Cold Spring Harb. Lab. Sym. 81, 189–205 (2016).

    Article  Google Scholar 

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Correspondence to Irina Matei or David Lyden.

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Matei, I., Rampersaud, S. & Lyden, D. Engineered niches model the onset of metastasis. Nat Biomed Eng 2, 885–887 (2018).

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