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IMPLANTED BIOMATERIALS

Engineered niches model the onset of metastasis

Nature Biomedical Engineering volume 2, pages 885–887 (2018)Cite this article

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A humanized biomaterial microenvironment that mimics the pre-metastatic niche captures disseminated tumour cells and recapitulates metastatic progression after implantation in xenografted mice.

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Fig. 1: Implantable humanized pre-metastatic niches for modelling disseminated tumour-cell seeding and metastatic progression.

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  1. Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA

    Irina Matei, Sham Rampersaud & David Lyden

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  1. Irina Matei
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  2. Sham Rampersaud
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  3. David Lyden
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Correspondence to Irina Matei or David Lyden.

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Matei, I., Rampersaud, S. & Lyden, D. Engineered niches model the onset of metastasis. Nat Biomed Eng 2, 885–887 (2018). https://doi.org/10.1038/s41551-018-0326-7

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