Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

IMMUNOTHERAPY

Checkpoint inhibition in the bone marrow

Nature Biomedical Engineering volume 2, pages 793–794 (2018)Cite this article

Subjects

The coupling of blood platelets bearing anti-programmed cell death protein 1 antibodies to haematopoietic stem cells enables delivery of checkpoint-blockade therapy to bone marrow to promote T-cell-mediated control of leukaemia in mice.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Re-activation of AML-targeting T cells via delivery of aPD-1 to the bone marrow of leukaemic mice by means of a platelet–HSC construct.

References

  1. Zhang, L., Gajewski, T. F. & Kline, J. Blood 114, 1545–1552 (2009).

    Article  CAS  Google Scholar 

  2. Boddu, P. et al. Leuk. Lymphoma 59, 790–802 (2018).

    Article  CAS  Google Scholar 

  3. Hu, Q. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-018-0310-2 (2018).

  4. Vidriales, M. B. et al. Ann. Hematol. 67, 217–222 (1993).

    Article  CAS  Google Scholar 

  5. Van den Hove, L. E. et al. Leuk. Res. 22, 175–184 (1998).

    Article  Google Scholar 

  6. Yang, H. et al. Leukemia 28, 1280–1288 (2014).

    Article  CAS  Google Scholar 

  7. Coles, S. J. et al. Leukemia 29, 1952–1954 (2015).

    Article  CAS  Google Scholar 

  8. Alexandrov, L. B. et al. Nature 500, 415–421 (2013).

    Article  CAS  Google Scholar 

  9. Roh, W. et al. Sci. Transl. Med. 9, eaah3560 (2017).

    Article  Google Scholar 

  10. Li, S. et al. Nat. Med. 22, 792–799 (2016).

    Article  CAS  Google Scholar 

  11. Geiger, T. L. & Rubnitz, J. E. Discov. Med. 19, 275–284 (2015).

    PubMed  PubMed Central  Google Scholar 

  12. Daver, N. et al. Leukemia 32, 1094–1105 (2018).

    Article  CAS  Google Scholar 

  13. Klinger, M., Benjamin, J., Kischel, R., Stienen, S. & Zugmaier, G. Immunol. Rev. 270, 193–208 (2016).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Molecular Genetics, German Cancer Research Center, Heidelberg, Germany

    Martina Seiffert

Authors
  1. Martina Seiffert
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Martina Seiffert.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Seiffert, M. Checkpoint inhibition in the bone marrow. Nat Biomed Eng 2, 793–794 (2018). https://doi.org/10.1038/s41551-018-0319-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41551-018-0319-6

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research