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Checkpoint inhibition in the bone marrow

The coupling of blood platelets bearing anti-programmed cell death protein 1 antibodies to haematopoietic stem cells enables delivery of checkpoint-blockade therapy to bone marrow to promote T-cell-mediated control of leukaemia in mice.

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Fig. 1: Re-activation of AML-targeting T cells via delivery of aPD-1 to the bone marrow of leukaemic mice by means of a platelet–HSC construct.


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Correspondence to Martina Seiffert.

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Seiffert, M. Checkpoint inhibition in the bone marrow. Nat Biomed Eng 2, 793–794 (2018).

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