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Muted fibrosis from protected islets

Nature Biomedical Engineering volume 2, pages 791–792 (2018)Cite this article

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Transplanting allogeneic pancreatic islets intraperitoneally by first encapsulating the islets within an alginate-based formulation results in reduced fibrosis and capsule clumping, and thus in improved islet survival.

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Fig. 1: Potential sites for the transplantation of microencapsulated pancreatic islets.

References

  1. Pepper, A. R. et al. Nat. Biotechnol. 33, 518–523 (2015).

    Article  CAS  Google Scholar 

  2. Berman, D. M. et al. Diabetes 65, 1350–1361 (2016).

    Article  CAS  Google Scholar 

  3. McCall, M. & James Shapiro, A. M. Cold Spring Harb. Perspect. Med. 2, a007823 (2012).

    Article  Google Scholar 

  4. Barshes, N. R. J. Leukoc. Biol. 77, 587–597 (2005).

    Article  CAS  Google Scholar 

  5. Shapiro, A. M. J. et al. N. Engl. J. Med. 343, 230–238 (2000).

    Article  CAS  Google Scholar 

  6. Vlahos, A. E., Cober, N. & Sefton, M. V. Proc. Natl Acad. Sci. USA 114, 9337–9342 (2017).

    Article  CAS  Google Scholar 

  7. Bochenek, M. A. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-018-0275–1 (2018).

    Article  Google Scholar 

  8. Calafiore, R. et al. Diabetes Care 29, 137–138 (2006).

    Article  Google Scholar 

  9. Basta, G. et al. Diabetes Care 34, 2406–2409 (2011).

    Article  CAS  Google Scholar 

  10. Vegas, A. J. et al. Nat. Med. 22, 306–311 (2016).

    Article  CAS  Google Scholar 

  11. Vegas, A. J. et al. Nat. Biotechnol. 34, 345–352 (2016).

    Article  CAS  Google Scholar 

  12. Doloff, J. C. et al. Nat. Mater. 16, 671–680 (2017).

    Article  CAS  Google Scholar 

  13. Veiseh, O. et al. Nat. Mater. 14, 643–651 (2015).

    Article  CAS  Google Scholar 

  14. Tomei, A. A. et al. Proc. Natl Acad. Sci. USA 111, 10514–10519 (2014).

    Article  CAS  Google Scholar 

  15. Kayaalp, C. World. J. Gastrointest. Surg. 7, 249–253 (2015).

    Article  Google Scholar 

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Authors and Affiliations

  1. Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada

    Alexander E. Vlahos & Michael V. Sefton

  2. Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada

    Michael V. Sefton

Authors
  1. Alexander E. Vlahos
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  2. Michael V. Sefton
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Correspondence to Michael V. Sefton.

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Vlahos, A.E., Sefton, M.V. Muted fibrosis from protected islets. Nat Biomed Eng 2, 791–792 (2018). https://doi.org/10.1038/s41551-018-0316-9

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