Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

REGENERATIVE MEDICINE

Macrophages rescue injured engineered muscle

Engineered skeletal muscle self-repairs when incorporating bone-marrow-derived macrophages, which prevent the apoptosis of resident muscle stem cells.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: BMDMs enhance the survival of adult MuSCs in 3D bioengineered skeletal muscle.

References

  1. Blau, H. M., Cosgrove, B. D. & Ho, A. T. V. Nat. Med. 21, 854–862 (2015).

    Article  CAS  Google Scholar 

  2. Bentzinger, C. F., Wang, Y. X., Dumont, N. A. & Rudnicki, M. A. EMBO Rep. 14, 1062–1072 (2013).

    Article  CAS  Google Scholar 

  3. Cosgrove, B. D. et al. Nat. Med. 20, 255–264 (2014).

    Article  CAS  Google Scholar 

  4. Sampath, S. C. et al. Nat. Commun. 9, 1531 (2018).

    Article  Google Scholar 

  5. Madl, C. M., Heilshorn, S. C. & Blau, H. M. Nature 557, 335–342 (2018).

    Article  CAS  Google Scholar 

  6. Quarta, M. et al. Nat. Biotechnol. 34, 752–759 (2016).

    Article  CAS  Google Scholar 

  7. Juhas, M., Engelmayr, G. C., Fontanella, A. N., Palmer, G. M. & Bursac, N. Proc. Natl Acad. Sci. USA 111, 5508–5513 (2014).

    Article  CAS  Google Scholar 

  8. Wang, Y. X. & Rudnicki, M. A. Nat. Rev. Mol. Cell Biol. 13, 127–133 (2012).

    Article  CAS  Google Scholar 

  9. Zhang, H. et al. Science 352, aaf2693 (2016).

    Google Scholar 

  10. Ho, A. T. V. et al. Proc. Natl Acad. Sci. USA 114, 6675–6684 (2017).

    CAS  PubMed  Google Scholar 

  11. Juhas, M. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-018-0290-2 (2018).

  12. Tidball, J. G. Nat. Rev. Immunol. 17, 165–178 (2017).

    Article  CAS  Google Scholar 

  13. Chazaud, B. et al. J. Cell Biol. 163, 1133–1143 (2003).

    Article  CAS  Google Scholar 

  14. Varga, T. et al. Immunity 45, 1038–1051 (2016).

    Article  CAS  Google Scholar 

  15. Madden, L., Juhas, M., Kraus, W. E., Truskey, G. A. & Bursac, N. eLife 4, e04885 (2015).

    Article  Google Scholar 

  16. Takebe, T., Zhang, B. & Radisic, M. Cell Stem Cell 21, 297–300 (2017).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Helen M. Blau.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wang, Y.X., Blau, H.M. Macrophages rescue injured engineered muscle. Nat Biomed Eng 2, 890–891 (2018). https://doi.org/10.1038/s41551-018-0312-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41551-018-0312-0

Search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research