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Hyperthermia-induced drug delivery in humans

Nature Biomedical Engineering volume 2, pages 637–639 (2018)Cite this article

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A clinical study shows the feasibility and safety of the intratumoral release of an anticancer drug encapsulated in thermosensitive liposomes by heating the patient’s tumour via focused ultrasound.

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Fig. 1: Hyperthermia-induced drug delivery.
Fig. 2: Hyperthermia via focused ultrasound.

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Authors and Affiliations

  1. Physical Sciences Platform, Sunnybrook Research Institute and Department of Medical Biophysics, and Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada

    Kullervo Hynynen

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  1. Kullervo Hynynen
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Correspondence to Kullervo Hynynen.

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Competing interests

K.H. owns stocks in, is a board member of and receives research funding from FUS Instruments Inc. (a manufacturer of pre-clinical ultrasound research devices) and Harmonic Inc. (which is developing thermal ablation devices for clinical use).

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Hynynen, K. Hyperthermia-induced drug delivery in humans. Nat Biomed Eng 2, 637–639 (2018). https://doi.org/10.1038/s41551-018-0297-8

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