Two drug-loaded nanoparticle formulations that preferentially accumulate within tumour-associated macrophages induce macrophage repolarization to a tumoricidal state that leads to potent antitumour activity in multiple murine models of cancer.
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References
Mantovani, A., Sozzani, S., Locati, M., Allavena, P. & Sica, A. Trends Immunol. 23, 549–555 (2002).
Sica, A. & Bronte, V. J. Clin. Invest. 117, 1155–1166 (2007).
Mantovani, A., Schioppa, T., Porta, C., Allavena, P. & Sica, A. Cancer Metastasis Rev. 25, 315–322 (2006).
Willingham, S. B. et al. Proc. Natl Acad. Sci. USA 109, 6662–6667 (2012).
Mantovani, A., Marchesi, F., Malesci, A., Laghi, L. & Allavena, P. Nat. Rev. Clin. Oncol. 14, 399–416 (2017).
Ngambenjawong, C., Gustafson, H. H. & Pun, S. H. Adv. Drug Deliv. Rev. 114, 206–221 (2017).
Nywening, T. M. et al. Lancet Oncol. 17, 651–662 (2016).
Chao, M. P. et al. Cell 142, 699–713 (2010).
Cieslewicz, M. et al. Proc. Natl Acad. Sci. USA 110, 15919–15924 (2013).
Beatty, G. L. et al. Science 331, 1612–1616 (2011).
De Henau, O. et al. Nature 539, 443–447 (2016).
Kaneda, M. M. et al. Nature 539, 437–442 (2016).
Rodell, C. B. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-018-0236-8 (2018).
Kulkarni, A. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-018-0254-6 (2018).
Keliher, E. J. et al. Bioconjugate Chem. 22, 2383–2389 (2011).
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Gustafson, H.H., Pun, S.H. Instructing macrophages to fight cancer. Nat Biomed Eng 2, 559–561 (2018). https://doi.org/10.1038/s41551-018-0276-0
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DOI: https://doi.org/10.1038/s41551-018-0276-0
