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Cancer immunotherapy

Instructing macrophages to fight cancer

Two drug-loaded nanoparticle formulations that preferentially accumulate within tumour-associated macrophages induce macrophage repolarization to a tumoricidal state that leads to potent antitumour activity in multiple murine models of cancer.

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Correspondence to Suzie H. Pun.

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https://doi.org/10.1038/s41551-018-0276-0

Fig. 1: Two strategies for the repolarization of TAMs from a tumour-permissive M2 to a tumour-reactive M1 phenotype, to induce tumour-cell death.