Cancer immunotherapy

Instructing macrophages to fight cancer

Two drug-loaded nanoparticle formulations that preferentially accumulate within tumour-associated macrophages induce macrophage repolarization to a tumoricidal state that leads to potent antitumour activity in multiple murine models of cancer.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Two strategies for the repolarization of TAMs from a tumour-permissive M2 to a tumour-reactive M1 phenotype, to induce tumour-cell death.

References

  1. 1.

    Mantovani, A., Sozzani, S., Locati, M., Allavena, P. & Sica, A. Trends Immunol. 23, 549–555 (2002).

    Article  PubMed  CAS  Google Scholar 

  2. 2.

    Sica, A. & Bronte, V. J. Clin. Invest. 117, 1155–1166 (2007).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  3. 3.

    Mantovani, A., Schioppa, T., Porta, C., Allavena, P. & Sica, A. Cancer Metastasis Rev. 25, 315–322 (2006).

    Article  PubMed  Google Scholar 

  4. 4.

    Willingham, S. B. et al. Proc. Natl Acad. Sci. USA 109, 6662–6667 (2012).

    Article  PubMed  Google Scholar 

  5. 5.

    Mantovani, A., Marchesi, F., Malesci, A., Laghi, L. & Allavena, P. Nat. Rev. Clin. Oncol. 14, 399–416 (2017).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  6. 6.

    Ngambenjawong, C., Gustafson, H. H. & Pun, S. H. Adv. Drug Deliv. Rev. 114, 206–221 (2017).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  7. 7.

    Nywening, T. M. et al. Lancet Oncol. 17, 651–662 (2016).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  8. 8.

    Chao, M. P. et al. Cell 142, 699–713 (2010).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  9. 9.

    Cieslewicz, M. et al. Proc. Natl Acad. Sci. USA 110, 15919–15924 (2013).

    Article  PubMed  Google Scholar 

  10. 10.

    Beatty, G. L. et al. Science 331, 1612–1616 (2011).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  11. 11.

    De Henau, O. et al. Nature 539, 443–447 (2016).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  12. 12.

    Kaneda, M. M. et al. Nature 539, 437–442 (2016).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  13. 13.

    Rodell, C. B. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-018-0236-8 (2018).

  14. 14.

    Kulkarni, A. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-018-0254-6 (2018).

  15. 15.

    Keliher, E. J. et al. Bioconjugate Chem. 22, 2383–2389 (2011).

    Article  CAS  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Suzie H. Pun.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Gustafson, H.H., Pun, S.H. Instructing macrophages to fight cancer. Nat Biomed Eng 2, 559–561 (2018). https://doi.org/10.1038/s41551-018-0276-0

Download citation

Further reading

Search

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing