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Cancer immunotherapy

Instructing macrophages to fight cancer

Nature Biomedical Engineering volume 2, pages 559–561 (2018)Cite this article

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Two drug-loaded nanoparticle formulations that preferentially accumulate within tumour-associated macrophages induce macrophage repolarization to a tumoricidal state that leads to potent antitumour activity in multiple murine models of cancer.

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Fig. 1: Two strategies for the repolarization of TAMs from a tumour-permissive M2 to a tumour-reactive M1 phenotype, to induce tumour-cell death.

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Authors and Affiliations

  1. Department of Bioengineering, University of Washington, Seattle, WA, USA

    Heather H. Gustafson & Suzie H. Pun

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  1. Heather H. Gustafson
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  2. Suzie H. Pun
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Correspondence to Suzie H. Pun.

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Gustafson, H.H., Pun, S.H. Instructing macrophages to fight cancer. Nat Biomed Eng 2, 559–561 (2018). https://doi.org/10.1038/s41551-018-0276-0

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