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Non-invasive chemogenetics

A technique combining focused ultrasound for opening the blood–brain barrier and virally encoded engineered G-protein-coupled receptors for promoting the expression of a gene targeting excitatory neurons enables the non-invasive stimulation of specific brain regions and cell types in mice.

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Fig. 1: Experimental strategy for the ATAC-mediated interrogation of circuits in fear learning.


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Correspondence to Caroline Menard or Scott J. Russo.

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Menard, C., Russo, S.J. Non-invasive chemogenetics. Nat Biomed Eng 2, 467–468 (2018).

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