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Non-invasive chemogenetics

Nature Biomedical Engineering volume 2, pages 467–468 (2018)Cite this article

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A technique combining focused ultrasound for opening the blood–brain barrier and virally encoded engineered G-protein-coupled receptors for promoting the expression of a gene targeting excitatory neurons enables the non-invasive stimulation of specific brain regions and cell types in mice.

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Fig. 1: Experimental strategy for the ATAC-mediated interrogation of circuits in fear learning.

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Authors and Affiliations

  1. Department of Psychiatry and Neuroscience, Faculty of Medicine & CERVO Brain Research Center, Université Laval, Quebec City, Quebec, Canada

    Caroline Menard

  2. Department of Neuroscience, Center for Affective Neuroscience, and the Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, USA

    Scott J. Russo

Authors
  1. Caroline Menard
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  2. Scott J. Russo
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Correspondence to Caroline Menard or Scott J. Russo.

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Menard, C., Russo, S.J. Non-invasive chemogenetics. Nat Biomed Eng 2, 467–468 (2018). https://doi.org/10.1038/s41551-018-0269-z

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