Non-invasive chemogenetics

A technique combining focused ultrasound for opening the blood–brain barrier and virally encoded engineered G-protein-coupled receptors for promoting the expression of a gene targeting excitatory neurons enables the non-invasive stimulation of specific brain regions and cell types in mice.

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Fig. 1: Experimental strategy for the ATAC-mediated interrogation of circuits in fear learning.


  1. 1.

    Russo, S. J. & Nestler, E. J. Nat. Rev. Neurosci. 14, 609–625 (2013).

    Article  PubMed  CAS  Google Scholar 

  2. 2.

    Canter, R. G., Penney, J. & Tsai, L. H. Nature 539, 187–196 (2016).

    Article  PubMed  Google Scholar 

  3. 3.

    Szablowski, J. O., Lee-Gosselin, A., Lue, B., Malounda, D. & Shapiro, M. G. Nat. Biomed. Eng. (2018).

  4. 4.

    Roth, B. L. Neuron 89, 683–694 (2016).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  5. 5.

    Sheikov, N., McDannold, N., Vykhodtseva, N., Jolesz, F. & Hynynen, K. Ultrasound Med. Biol. 30, 979–989 (2004).

    Article  PubMed  Google Scholar 

  6. 6.

    McDannold, N., Clement, G. T., Black, P., Jolesz, F. & Hynynen, K. Neurosurgery 66, 323–332 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  7. 7.

    First Alzheimer’s trial with focused ultrasound begins. Focused Ultrasound Foundation (2 May 2017).

  8. 8.

    Aschauer, D. F., Kreuz, S. & Rumpel, S. PLoS ONE 8, e76310 (2013).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  9. 9.

    Wang, S., Olumolade, O. O., Sun, T., Samiotaki, G. & Konofagou, E. E. Gene Ther. 22, 104–110 (2015).

    Article  PubMed  CAS  Google Scholar 

  10. 10.

    Izquierdo, I., Furini, C. R. & Myskiw, J. C. Physiol. Rev. 96, 695–750 (2016).

    Article  PubMed  Google Scholar 

  11. 11.

    Heffner, C. S. et al. Nat. Commun. 3, 1218 (2012).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  12. 12.

    Chan, K. Y. et al. Nat. Neurosci. 20, 1172–1179 (2017).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  13. 13.

    Gomez, J. L. et al. Science 357, 503–507 (2017).

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Caroline Menard or Scott J. Russo.

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Menard, C., Russo, S.J. Non-invasive chemogenetics. Nat Biomed Eng 2, 467–468 (2018).

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