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Towards superior dendritic-cell vaccines for cancer therapy

Potent dendritic-cell cancer vaccines could be used to induce functional antitumour immunity without off-target toxicity.

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Fig. 1: Classical and newly discovered DC subsets.
Fig. 2: Expression of selected immune checkpoint factors on in vitro stimulated CD141+ DCs, MoDCs and pDCs.

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Acknowledgements

This work was supported by the National Institutes of Health grants RO1CA201189, R01CA180913 and R01AI081848, the Cancer Research Institute and the Melanoma Research Alliance. N.B. is a member of the Parker Institute for Cancer Immunotherapy, which supports the Icahn School of Medicine at Mount Sinai, NY, Cancer Immunotherapy Program.

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Correspondence to Nina Bhardwaj.

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N.B. is on the senior advisory board of Check Point Sciences, Curevac, Neon and Inception, and a consultant for Genentech. All potential conflicts of interest are being managed by the Conflict of Interest Office, Icahn School of Medicine at Mount Sinai. M.S., S.B. and V.R. declare no competing interests.

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Saxena, M., Balan, S., Roudko, V. et al. Towards superior dendritic-cell vaccines for cancer therapy. Nat Biomed Eng 2, 341–346 (2018). https://doi.org/10.1038/s41551-018-0250-x

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