A scalable and fast method for profiling single-molecule protein–protein interactions predicts the sensitivity of cells to inhibitors of the epidermal growth factor receptor, which is typically overexpressed in cancer.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 /Â 30Â days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$99.00 per year
only $8.25 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Lemmon, M. A. & Schlessinger, J. Cell 141, 1117–1134 (2010).
Yao, Z., Petschnigg, J., Ketteler, R. & Stagljar, I. Nat. Chem. Biol. 11, 387–397 (2015).
Yarden, Y. & Pines, G. Nat. Rev. Cancer 12, 553–563 (2012).
Mishra, R., Hanker, A. B. & Garrett, J. T. Oncotarget 8, 114371–114392 (2017).
Snider, J. et al. Mol. Syst. Biol. 11, 848 (2015).
Gingras, A. C., Gstaiger, M., Raught, B. & Aebersold, R. Nat. Rev. Mol. Cell Biol. 8, 645–654 (2007).
Yao, Z. et al. Mol. Cell 65, 347–360 (2017).
Petschnigg, J. et al. Nat. Methods 11, 585–592 (2014).
Blakely, B. T. et al. Nat. Biotechnol. 18, 218–222 (2000).
Lee, H.-W. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-018-0212-3 (2018).
Janes, M. R. et al. Cell 172, 578–589 (2018).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Saraon, P., Grozavu, I. & Stagljar, I. Testing cancer inhibitors at scale. Nat Biomed Eng 2, 203–204 (2018). https://doi.org/10.1038/s41551-018-0226-x
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41551-018-0226-x
